Ontology highlight
ABSTRACT:
SUBMITTER: Rezaei M
PROVIDER: S-EPMC5038467 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Rezaei Maryam M Hashemi Mohammad M Sanaei Sara S Mashhadi Mohammad Ali MA Hashemi Seyed Mehdi SM Bahari Gholamreza G Taheri Mohsen M
Biomedical reports 20160808 4
Flap endonuclease 1 (FEN1), a DNA repair protein, is important in preventing carcinogenesis. Two functional germ line variants -69G>A (rs174538) and +4150G>T (rs4246215) in the <i>FEN1</i> gene have been associated with risk of various types of cancer. The aim of the present study was to evaluate the possible impact of <i>FEN1</i> polymorphisms on risk of breast cancer (BC) in a sample of Iranian subjects. The <i>FEN1</i> -69G>A and +4150G>T polymorphisms were analyzed in a case-control study th ...[more]