Dispersion Curve Engineering of TiO?/Silver Hybrid Substrates for Enhanced Surface Plasmon Resonance Detection.

ABSTRACT: As surface plasmon resonance (SPR)-based biosensors are well translated into biological, chemical, environmental, and clinical fields, it is critical to further realize stable and sustainable systems, avoiding oxidation susceptibility of metal films-in particular, silver substrates. We report an enhanced SPR detection performance by incorporating a TiO? layer on top of a thin silver film. A uniform TiO? film fabricated by electron beam evaporation at room temperature is an effective alternative in bypassing oxidation of a silver film. Based on our finding that the sensor sensitivity is strongly correlated with the slope of dispersion curves, SPR sensing results obtained by parylene film deposition shows that TiO?/silver hybrid substrates provide notable sensitivity improvement compared to a conventional bare silver film, which confirms the possibility of engineering the dispersion characteristic according to the incidence wavelength. The reported SPR structures with TiO? films enhance the sensitivity significantly in water and air environments and its overall qualitative trend in sensitivity improvement is consistent with numerical simulations. Thus, we expect that our approach can extend the applicability of TiO?-mediated SPR biosensors to highly sensitive detection for biomolecular binding events of low concentrations, while serving a practical and reliable biosensing platform.

SUBMITTER: El-Gohary SH 

PROVIDER: S-EPMC5038720 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature