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A genome-wide investigation of food addiction.


ABSTRACT: OBJECTIVE:Evidence of parallels between drug addiction and eating behavior continues to accumulate. Genetic studies of addictive substances have yielded a number of susceptibility loci that point to common higher order genetic pathways underlying addiction. It was hypothesized that a genome-wide association study (GWAS) of food addiction would yield significant enrichment in genes and pathways linked to addiction. METHODS:A GWAS of food addiction, determined by the modified Yale Food Addiction Scale (mYFAS), was conducted among 9,314 women of European ancestry, and results for enrichment of single-nucleotide polymorphisms (SNPs) (n?=?44), genes (n?=?238), and pathways (n?=?11) implicated in drug addiction were examined. RESULTS:Two loci met GW-significance (P?

SUBMITTER: Cornelis MC 

PROVIDER: S-EPMC5038917 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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A genome-wide investigation of food addiction.

Cornelis Marilyn C MC   Flint Alan A   Field Alison E AE   Kraft Peter P   Han Jiali J   Rimm Eric B EB   van Dam Rob M RM  

Obesity (Silver Spring, Md.) 20160423 6


<h4>Objective</h4>Evidence of parallels between drug addiction and eating behavior continues to accumulate. Genetic studies of addictive substances have yielded a number of susceptibility loci that point to common higher order genetic pathways underlying addiction. It was hypothesized that a genome-wide association study (GWAS) of food addiction would yield significant enrichment in genes and pathways linked to addiction.<h4>Methods</h4>A GWAS of food addiction, determined by the modified Yale F  ...[more]

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