Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC5038981 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Yang Hui H Matsumoto Yoshihiro Y Trujillo Kelly M KM Lees-Miller Susan P SP Osley Mary Ann MA Tomkinson Alan E AE
DNA repair 20150421
DNA double strand breaks (DSB)s often require end processing prior to joining during their repair by non-homologous end joining (NHEJ). Although the yeast proteins, Pol4, a Pol X family DNA polymerase, and Rad27, a nuclease, participate in the end processing reactions of NHEJ, the mechanisms underlying the recruitment of these factors to DSBs are not known. Here we demonstrate that Nej1, a NHEJ factor that interacts with and modulates the activity of the NHEJ DNA ligase complex (Dnl4/Lif1), phys ...[more]