Dataset Information

XPG Gene Polymorphisms Contribute to Colorectal Cancer Susceptibility: A Two-Stage Case-Control Study.

ABSTRACT: Previous studies have reported that xeroderma pigmentosum group G (XPG) gene polymorphisms may modulate colorectal cancer (CRC) susceptibility. In this study, we performed a two-stage case-control study to comprehensively investigate the associations of five polymorphisms in the XPG gene with CRC risk in 1,901 cases and 1,976 controls from Southern China, including rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C and rs873601 G>A. After combining data from two stages, we found that three of the studied polymorphisms (rs2094258 C>T, rs751402 C>T, and rs873601 G>A) were significantly associated with CRC susceptibility. After adjustment for age and gender, multivariate logistic regression analysis indicated that carriers of the rs2094258 T alleles had an increased CRC risk [CT vs. CC: adjusted odds ratio (OR)=1.17, 95% confidence interval (CI)=1.01-1.36; TT vs. CC: adjusted OR=1.49, 95% CI=1.18-1.89; TT vs. CT/CC: adjusted OR=1.38, 95% CI=1.10-1.72]. Likely, rs873601 A allele also conferred increased CRC susceptibility. In contrast, a protective association was identified between rs751402 C>T polymorphism and the risk of CRC. In summary, our results indicated that these three polymorphisms were found to associate with CRC susceptibility in a Southern Chinese population.

SUBMITTER: Hua RX

PROVIDER: S-EPMC5039395 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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XPG Gene Polymorphisms Contribute to Colorectal Cancer Susceptibility: A Two-Stage Case-Control Study.

Hua Rui-Xi RX Zhuo Zhen-Jian ZJ Zhu Jinhong J Zhang Shao-Dan SD Xue Wen-Qiong WQ Zhang Jiang-Bo JB Xu Hong-Mei HM Li Xi-Zhao XZ Zhang Pei-Fen PF He Jing J Jia Wei-Hua WH

Journal of Cancer 20160806 12

Previous studies have reported that xeroderma pigmentosum group G (XPG) gene polymorphisms may modulate colorectal cancer (CRC) susceptibility. In this study, we performed a two-stage case-control study to comprehensively investigate the associations of five polymorphisms in the XPG gene with CRC risk in 1,901 cases and 1,976 controls from Southern China, including rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C and rs873601 G>A. After combining data from two stage ...[more]

PMID: 27698911

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Project description:Exposure to environmental carcinogens can cause damages to DNA. If not properly repaired, the DNA damages may increase the risk of carcinogenesis. Xeroderma pigmentosum group G (XPG) gene is an essential gene in the nucleotide excision repair (NER) pathway. The association between XPG polymorphisms and cancer susceptibility has been the focus of attention in the molecular epidemiology of cancer. However, the conclusions have been divergent. Therefore, we conducted a comprehensive meta-analysis to precisely evaluate the association of 3 frequently investigated XPG polymorphisms (rs751402, rs873601, and rs2296147) with cancer risk.Pubmed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) were searched for relevant studies in English and Chinese. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the association between XPG polymorphisms (rs751402, rs873601, and rs2296147) and cancer risk.Twenty-three studies were included. Overall, there was no significant association between rs751402 polymorphism and overall cancer risk under the 5 gene models. However, we observed strong correlation between rs751402 polymorphism and gastric cancer (C vs T: OR=1.21, 95% CI?=?1.00-1.26, P?=?.045; TC vs CC: OR?=?1.12, 95% CI?=?1.00-1.24, P?=?.041; TC/TT vs CC: OR?=?1.13, 95% CI?=?1.02-1.26, P?=?.020). There was a significant correlation between rs873601 polymorphism and cancer risk under the homozygous model (GG vs AA: OR?=?1.16, 95% CI?=?1.07-1.26, P?=?.001). Moreover, significant association with breast cancer was detected for rs873601 polymorphism under the allele contrast model (G vs A: OR?=?1.10, 95% CI?=?1.02-1.20, P?=?.021). In the subgroup of Asian, rs873601 polymorphism was related to the susceptibility to cancer (G vs A: OR?=?1.07, 95% CI?=?1.03-1.12, P?=?.010; GG vs AA: OR?=?1.15, 95% CI?=?1.06-1.26, P?=?.001; AG/AA vs GG: OR?=?1.08, 95% CI?=?1.01-1.15, P?=?.031; AA vs AG/GG: OR?=?1.13, 95% CI?=?1.05-1.21, P?=?.001). Significant association between rs2296147 polymorphism and cancer risk were observed in Asian population (CT vs TT: OR?=?0.93, 95% CI?=?0.87-0.99, P?=?.036).Our meta-analysis suggested that the rs873601 polymorphism was significantly associated with overall cancer risk. The moderate effects of rs751402 and rs2296147 polymorphism on cancer susceptibility might be highly dependent on cancer type and ethnicity, respectively. Large studies are needed to validate our findings, especially in Caucasian and African population.

Dataset Information

XPG Gene Polymorphisms Contribute to Colorectal Cancer Susceptibility: A Two-Stage Case-Control Study.

Publications

<i>XPG</i> Gene Polymorphisms Contribute to Colorectal Cancer Susceptibility: A Two-Stage Case-Control Study.

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