Ontology highlight
ABSTRACT:
SUBMITTER: Yan N
PROVIDER: S-EPMC5039414 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Yan Naihong N Cheng Lin L Cho Kinsang K Malik Muhammad Taimur A MT Xiao Lirong L Guo Chenying C Yu Honghua H Zhu Ruilin R Rao Rajesh C RC Chen Dong Feng DF
Scientific reports 20160928
Some adult-onset disorders may be linked to dysregulated embryonic development, yet the mechanisms underlying this association remain poorly understood. Congenital retinal degenerative diseases are blinding disorders characterized by postnatal degeneration of photoreceptors, and affect nearly 2 million individuals worldwide, but ∼50% do not have a known mutation, implicating contributions of epigenetic factors. We found that embryonic deletion of the histone methyltransferase (HMT) Ezh2 from all ...[more]