Ontology highlight
ABSTRACT:
SUBMITTER: Li JH
PROVIDER: S-EPMC5039541 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Li Jun-Hui JH Li Shan S Zhi Zi-Jian ZJ Yan Lu-Feng LF Ye Xing-Qian XQ Ding Tian T Yan Lei L Linhardt Robert John RJ Chen Shi-Guo SG
Marine drugs 20160921 9
Fucosylated chondroitin sulfate (fCS) from sea cucumber <i>Isostichopus badionotus</i> (fCS-<i>Ib</i>) with a chondroitin sulfate type E (CSE) backbone and 2,4-<i>O</i>-sulfo fucose branches has shown excellent anticoagulant activity although has also show severe adverse effects. Depolymerization represents an effective method to diminish this polysaccharide's side effects. The present study reports a modified controlled Fenton system for degradation of fCS-<i>Ib</i> and the anticoagulant activi ...[more]