Telomerase Activation in Hematological Malignancies.
Ontology highlight
ABSTRACT:
SUBMITTER: Ropio J
PROVIDER: S-EPMC5039560 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Telomerase Activation in Hematological Malignancies.
Ropio Joana J Merlio Jean-Philippe JP Soares Paula P Chevret Edith E
Genes 20160907 9
Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT) is a complex process, and unveiling the mechanisms behind its reactivation is an important step for the development of diagnostic and therapeutic applications. Here, we review the main mechanisms of ...[more]
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