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Telomerase Activation in Hematological Malignancies.

ABSTRACT: Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT) is a complex process, and unveiling the mechanisms behind its reactivation is an important step for the development of diagnostic and therapeutic applications. Here, we review the main mechanisms of telomerase activation and the associated hematologic malignancies.

SUBMITTER: Ropio J 

PROVIDER: S-EPMC5039560 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Telomerase Activation in Hematological Malignancies.

Ropio Joana J   Merlio Jean-Philippe JP   Soares Paula P   Chevret Edith E  

Genes 20160907 9

Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT) is a complex process, and unveiling the mechanisms behind its reactivation is an important step for the development of diagnostic and therapeutic applications. Here, we review the main mechanisms of  ...[more]

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