Ontology highlight
ABSTRACT:
SUBMITTER: Thon M
PROVIDER: S-EPMC5039638 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Thon Mina M Hosoi Toru T Ozawa Koichiro K
Scientific reports 20160928
Leptin, an adipocyte-derived hormone, centrally regulates energy homeostasis. Overlaps in the regulation of glucose and energy homeostasis have been reported between leptin and insulin. However, the effects of insulin on leptin's actions in the central nervous system (CNS) have not yet been elucidated in detail. In the present study, we found that insulin potentiated leptin's actions through GRP78 in the neuronal cell line, SH-SY5Y-ObRb. Since insulin induces GRP78, we speculated that it may als ...[more]