Ontology highlight
ABSTRACT:
SUBMITTER: Tong T
PROVIDER: S-EPMC5039768 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Scientific reports 20160928
Adenylyl cyclase 3 (Adcy3), a member of the mammalian adenylyl cyclase family responsible for generating the second messenger cAMP, has long been known to play an essential role in olfactory signal transduction. Here, we demonstrated that Adcy3 heterozygous null mice displayed increased visceral adiposity in the absence of hyperphagia and developed abnormal metabolic features characterized by impaired insulin sensitivity, dyslipidemia, and increased plasma levels of proinflammatory cytokines on ...[more]