Altered resonance properties of somatosensory responses in mice deficient for the schizophrenia risk gene Neuregulin 1.

ABSTRACT: To reveal the neuronal underpinnings of sensory processing deficits in patients with schizophrenia, previous studies have investigated brain activity in response to sustained sensory stimulation at various frequencies. This paradigm evoked neural activity at the stimulation frequency and harmonics thereof. During visual and auditory stimulation that elicited enhanced or 'resonant' responses in healthy controls, patients with schizophrenia displayed reduced activity. The present study sought to elucidate the cellular basis of disease-related deficits in sensory resonance properties using mice heterozygous for the schizophrenia susceptibility gene Neuregulin 1 (NRG1). We applied repetitive whisker stimulation at 1-15 Hz, a range relevant to whisking behavior in mice, and measured cellular ac

SUBMITTER: Barz CS 

PROVIDER: S-EPMC5040624 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature