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Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study.

ABSTRACT: Acute pulmonary embolism (PE) is a frequent cause of death and serious disability. The risk of PE-associated mortality and morbidity extends far beyond the acute phase of the disease. In earlier follow-up studies, as many as 30?% of the patients died during a follow-up period of up to 3 years, and up to 50?% of patients continued to complain of dyspnea and/or poor physical performance 6 months to 3 years after the index event. The most feared 'late sequela' of PE is chronic thromboembolic pulmonary hypertension (CTEPH), the true incidence of which remains obscure due to the large margin of error in the rates reported by mostly small, single-center studies. Moreover, the functional and hemodynamic changes corresponding to early, possibly reversible stages of CTEPH, have not been systematically investigated. The ongoing Follow-Up after acute pulmonary embolism (FOCUS) study will prospectively enroll and systematically follow, over a 2-year period and with a standardized comprehensive program of clinical, echocardiographic, functional and laboratory testing, a large multicenter prospective cohort of 1000 unselected patients (all-comers) with acute symptomatic PE. FOCUS will possess adequate power to provide answers to relevant remaining questions regarding the patients' long-term morbidity and mortality, and the temporal pattern of post-PE abnormalities. It will hopefully provide evidence for future guideline recommendations regarding the selection of patients for long-term follow-up after PE, the modalities which this follow-up should include, and the findings that should be interpreted as indicating progressive functional and hemodynamic post-PE impairment, or the development of CTEPH.

SUBMITTER: Konstantinides SV

PROVIDER: S-EPMC5040729 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature

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Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study.

Konstantinides Stavros V SV Barco Stefano S Rosenkranz Stephan S Lankeit Mareike M Held Matthias M Gerhardt Felix F Bruch Leonard L Ewert Ralf R Faehling Martin M Freise Julia J Ghofrani Hossein-Ardeschir HA Grünig Ekkehard E Halank Michael M Heydenreich Nadine N Hoeper Marius M MM Leuchte Hanno H HH Mayer Eckhard E Meyer F Joachim FJ Neurohr Claus C Opitz Christian C Pinto Antonio A Seyfarth Hans-Jürgen HJ Wachter Rolf R Zäpf Bianca B Wilkens Heinrike H Binder Harald H Wild Philipp S PS

Journal of thrombosis and thrombolysis 20161101 4

Acute pulmonary embolism (PE) is a frequent cause of death and serious disability. The risk of PE-associated mortality and morbidity extends far beyond the acute phase of the disease. In earlier follow-up studies, as many as 30 % of the patients died during a follow-up period of up to 3 years, and up to 50 % of patients continued to complain of dyspnea and/or poor physical performance 6 months to 3 years after the index event. The most feared 'late sequela' of PE is chronic thromboembolic pulmon ...[more]

PMID: 27577542

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Dataset Information

Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study.

Publications

Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study.

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