Ontology highlight
ABSTRACT:
SUBMITTER: Kuga T
PROVIDER: S-EPMC5041083 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kuga Takahisa T Kume Hideaki H Adachi Jun J Kawasaki Naoko N Shimizu Maiko M Hoshino Isamu I Matsubara Hisahiro H Saito Youhei Y Nakayama Yuji Y Tomonaga Takeshi T
Scientific reports 20160929
In some fibroblasts, casein kinase 1α (CK1α) is localized to nuclear speckles, which are sub-nuclear compartments supplying splicing factors, whereas it is recruited on keratin filaments in colorectal cancer cells such as DLD1 cells. In order to obtain a deeper understanding of why CK1α is localized to these different subcellular sites, we herein elucidated the mechanisms underlying its localization to nuclear speckles. CK1α and FAM83H were localized to nuclear speckles in RKO and WiDr colorecta ...[more]