RNAlien - Unsupervised RNA family model construction.
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ABSTRACT:
SUBMITTER: Eggenhofer F
PROVIDER: S-EPMC5041467 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
RNAlien - Unsupervised RNA family model construction.
Eggenhofer Florian F Hofacker Ivo L IL Höner Zu Siederdissen Christian C
Nucleic acids research 20160621 17
Determining the function of a non-coding RNA requires costly and time-consuming wet-lab experiments. For this reason, computational methods which ascertain the homology of a sequence and thereby deduce functionality and family membership are often exploited. In this fashion, newly sequenced genomes can be annotated in a completely computational way. Covariance models are commonly used to assign novel RNA sequences to a known RNA family. However, to construct such models several examples of the f ...[more]
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