In Vivo Detection of Reactive Oxygen Species and Redox Status in Caenorhabditis elegans.

ABSTRACT:

Significance

Due to its large families of redox-active enzymes, genetic amenability, and complete transparency, the nematode Caenorhabditis elegans has the potential to become an important model for the in vivo study of redox biology.

Recent advances

The recent development of several genetically encoded ratiometric reactive oxygen species (ROS) and redox sensors has revolutionized the quantification and precise localization of ROS and redox signals in living organisms. Only few exploratory studies have applied these sensors in C. elegans and undoubtedly much remains to be discovered in this model. As a follow-up to our recent findings that the C. elegans somatic gonad uses superoxide and hydrogen peroxide (H2O2) signals to communicate with the germline, we here analyze the p

SUBMITTER: Braeckman BP 

PROVIDER: S-EPMC5041511 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature