Ontology highlight
ABSTRACT:
SUBMITTER: Tabbo F
PROVIDER: S-EPMC5041889 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Tabbò Fabrizio F Pizzi Marco M Kyriakides Peter W PW Ruggeri Bruce B Inghirami Giorgio G
Oncotarget 20160501 18
Cancer biology relies on intrinsic and extrinsic deregulated pathways, involving a plethora of intra-cellular and extra-cellular components. Tyrosine kinases are frequently deregulated genes, whose aberrant expression is often caused by major cytogenetic events (e.g. chromosomal translocations). The resulting tyrosine kinase fusions (TKFs) prompt the activation of oncogenic pathways, determining the biological and clinical features of the associated tumors. First reported half a century ago, onc ...[more]