Ontology highlight
ABSTRACT:
SUBMITTER: Benitez-Buelga C
PROVIDER: S-EPMC5041946 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Benitez-Buelga Carlos C Vaclová Tereza T Ferreira Sofia S Urioste Miguel M Inglada-Perez Lucia L Soberón Nora N Blasco Maria A MA Osorio Ana A Benitez Javier J
Oncotarget 20160501 18
We have recently shown that rs2304277 variant in the OGG1 glycosidase gene of the Base Excision Repair pathway can increase ovarian cancer risk in BRCA1 mutation carriers. In the present study, we aimed to explore the role of this genetic variant on different genome instability hallmarks to explain its association with cancer risk.We have evaluated the effect of this polymorphism on OGG1 transcriptional regulation and its contribution to telomere shortening and DNA damage accumulation. For that, ...[more]