Ontology highlight
ABSTRACT:
SUBMITTER: Tanaka W
PROVIDER: S-EPMC5042166 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Tanaka Wataru W Shoji Mitsuo M Tomoike Fumiaki F Ujiie Yuzuru Y Hanaoka Kyohei K Harada Ryuhei R Kayanuma Megumi M Kamiya Katsumasa K Ishida Toyokazu T Masui Ryoji R Kuramitsu Seiki S Shigeta Yasuteru Y
Biophysics and physicobiology 20160608
A uridine-cytidine kinase (UCK) catalyzes the phosphorylation of uridine (Urd) and cytidine (Cyd) and plays a significant role in the pyrimidine-nucleotide salvage pathway. Unlike ordinary ones, UCK from <i>Thermus thermophilus</i> HB8 (ttCK) loses catalytic activity on Urd due to lack of a substrate binding ability and possesses an unusual amino acid, i.e. tyrosine 93 (Tyr93) at the binding site, whereas histidine (His) is located in the other UCKs. Mutagenesis experiments revealed that a repla ...[more]