Ontology highlight
ABSTRACT:
SUBMITTER: Amorim JP
PROVIDER: S-EPMC5042396 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Genes 20160919 9
Telomeres are responsible for protecting chromosome ends in order to prevent the loss of coding DNA. Their maintenance is required for achieving immortality by neoplastic cells and can occur by upregulation of the telomerase enzyme or through a homologous recombination-associated process, the alternative lengthening of telomeres (ALT). The precise mechanisms that govern the activation of ALT or telomerase in tumor cells are not fully understood, although cellular origin may favor one of the othe ...[more]