Ontology highlight
ABSTRACT:
SUBMITTER: Gao R
PROVIDER: S-EPMC5042845 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Gao Ruli R Davis Alexander A McDonald Thomas O TO Sei Emi E Shi Xiuqing X Wang Yong Y Tsai Pei-Ching PC Casasent Anna A Waters Jill J Zhang Hong H Meric-Bernstam Funda F Michor Franziska F Navin Nicholas E NE
Nature genetics 20160815 10
Aneuploidy is a hallmark of breast cancer; however, knowledge of how these complex genomic rearrangements evolve during tumorigenesis is limited. In this study, we developed a highly multiplexed single-nucleus sequencing method to investigate copy number evolution in patients with triple-negative breast cancer. We sequenced 1,000 single cells from tumors in 12 patients and identified 1-3 major clonal subpopulations in each tumor that shared a common evolutionary lineage. For each tumor, we also ...[more]