Ontology highlight
ABSTRACT:
SUBMITTER: Sant'Anna R
PROVIDER: S-EPMC5043269 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Sant'Anna Ricardo R Fernández Maria Rosario MR Batlle Cristina C Navarro Susanna S de Groot Natalia S NS Serpell Louise L Ventura Salvador S
Scientific reports 20160930
Amyloids consist of repetitions of a specific polypeptide chain in a regular cross-β-sheet conformation. Amyloid propensity is largely determined by the protein sequence, the aggregation process being nucleated by specific and short segments. Prions are special amyloids that become self-perpetuating after aggregation. Prions are responsible for neuropathology in mammals, but they can also be functional, as in yeast prions. The conversion of these last proteins to the prion state is driven by pri ...[more]