Dataset Information

The impact of MTHFR 677C???T risk knowledge on changes in folate intake: findings from the Food4Me study.

ABSTRACT: BACKGROUND:It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from the Food4Me study. This was a 6-month Internet-based randomised controlled trial conducted across seven centres in Europe where individuals received either general healthy eating advice or varying levels of personalised nutrition advice. Participants who received genotype-based personalised advice were informed whether they had the risk (CT/TT) (n?=?178) or non-risk (CC) (n?=?141) alleles of the methylenetetrahydrofolate reductase (MTHFR) gene in relation to cardiovascular health and the importance of a sufficient intake of folate. General linear model analysis was used to assess changes in folate intake between the MTHFR risk, MTHFR non-risk and control groups from baseline to month 6 of the intervention. RESULTS:There were no differences between the groups for age, gender or BMI. However, there was a significant difference in country distribution between the groups (p?=?0.010). Baseline folate intakes were 412?±?172, 391?±?190 and 410?±?186 ?g per 10 MJ for the risk, non-risk and control groups, respectively. There were no significant differences between the three groups in terms of changes in folate intakes from baseline to month 6. Similarly, there were no changes in reported intake of food groups high in folate. CONCLUSIONS:These results suggest that knowledge of MTHFR 677C???T genotype did not improve folate intake in participants with the risk variant compared with those with the non-risk variant. TRIAL REGISTRATION:ClinicalTrials.gov NCT01530139.

SUBMITTER: O'Donovan CB

PROVIDER: S-EPMC5043523 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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The impact of <i>MTHFR</i> 677C → T risk knowledge on changes in folate intake: findings from the Food4Me study.

O'Donovan Clare B CB Walsh Marianne C MC Forster Hannah H Woolhead Clara C Celis-Morales Carlos C Fallaize Rosalind R Macready Anna L AL Marsaux Cyril F M CF Navas-Carretero Santiago S San-Cristobal Rodrigo R Kolossa Silvia S Mavrogianni Christina C Lambrinou Christina P CP Moschonis George G Godlewska Magdalena M Surwillo Agnieszka A Bouwman Jildau J Grimaldi Keith K Traczyk Iwona I Drevon Christian A CA Daniel Hannelore H Manios Yannis Y Martinez J Alfredo JA Saris Wim H M WH Lovegrove Julie A JA Mathers John C JC Gibney Michael J MJ Brennan Lorraine L Gibney Eileen R ER

Genes & nutrition 20160929

<h4>Background</h4>It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from the Food4Me study. This was a 6-month Internet-based randomised controlled trial conducted across seven centres in Europe where individuals received either general healthy eating advice or varying levels of personalised nutrition advice. Participants who received genotype- ...[more]

PMID: 27708721

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Project description:BackgroundGenetic polymorphisms can explain some of the population- and individual-based variations in nutritional status biomarkers.ObjectiveWe sought to screen the entire human genome for common genetic polymorphisms that influence folate-status biomarkers in healthy individuals.DesignWe carried out candidate gene analyses and genome-wide association scans in 2232 young, healthy Irish subjects to evaluate which common genetic polymorphisms influence red blood cell folate, serum folate, and plasma total homocysteine.ResultsThe 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C→T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 × 10-17), serum folate (P = 2.82 × 10-11), and plasma total homocysteine (P = 1.26 × 10-19) concentrations. A second polymorphism in the MTHFR gene (rs3753584, P = 1.09 × 10-11) was the only additional MTHFR variant to exhibit any significant independent effect on red blood cell folate. Other MTHFR variants, including the 1298A→C variant (rs1801131), appeared to reach genome-wide significance, but these variants shared linkage disequilibrium with MTHFR 677C→T and were not significant when analyzed in MTHFR 677CC homozygotes. No additional non-MTHFR modifiers of red blood cell or plasma folate were detected. Two additional genome-wide significant modifiers of plasma homocysteine were found in the region of the dipeptidase 1 (DPEP1) gene on chromosome 16 and the Twist neighbor B (TWISTNB) gene on chromosome 7.ConclusionsThe MTHFR 677C→T variant is the predominant genetic modifier of folate status biomarkers in this healthy Irish population. It is not necessary to determine MTHFR 677C→T genotype to evaluate folate status because its effect is reflected in concentrations of standard folate biomarkers. The MTHFR 1298A→C variant had no independent effect on folate status biomarkers. To our knowledge, this is the first genome-wide association study report on red blood cell folate and the first report of an association between homocysteine and TWISTNB.

Project description:BackgroundThe effect of personalised nutrition advice on discretionary foods intake is unknown. To date, two national classifications for discretionary foods have been derived. This study examined changes in intake of discretionary foods and beverages following a personalised nutrition intervention using these two classifications.MethodsParticipants were recruited into a 6-month RCT across seven European countries (Food4Me) and were randomised to receive generalised dietary advice (control) or one of three levels of personalised nutrition advice (based on diet [L1], phenotype [L2] and genotype [L3]). Dietary intake was derived from an FFQ. An analysis of covariance was used to determine intervention effects at month 6 between personalised nutrition (overall and by levels) and control on i) percentage energy from discretionary items and ii) percentage contribution of total fat, SFA, total sugars and salt to discretionary intake, defined by Food Standards Scotland (FSS) and Australian Dietary Guidelines (ADG) classifications.ResultsOf the 1607 adults at baseline, n = 1270 (57% female) completed the intervention. Percentage sugars from FSS discretionary items was lower in personalised nutrition vs control (19.0 ± 0.37 vs 21.1 ± 0.65; P = 0.005). Percentage energy (31.2 ± 0.59 vs 32.7 ± 0.59; P = 0.031), percentage total fat (31.5 ± 0.37 vs 33.3 ± 0.65; P = 0.021), SFA (36.0 ± 0.43 vs 37.8 ± 0.75; P = 0.034) and sugars (31.7 ± 0.44 vs 34.7 ± 0.78; P < 0.001) from ADG discretionary items were lower in personalised nutrition vs control. There were greater reductions in ADG percentage energy and percentage total fat, SFA and salt for those randomised to L3 vs L2.ConclusionsCompared with generalised dietary advice, personalised nutrition advice achieved greater reductions in discretionary foods intake when the classification included all foods high in fat, added sugars and salt. Future personalised nutrition approaches may be used to target intake of discretionary foods.Trial registrationClinicaltrials.gov NCT01530139 . Registered 9 February 2012.

Dataset Information

The impact of MTHFR 677C???T risk knowledge on changes in folate intake: findings from the Food4Me study.

Publications

The impact of <i>MTHFR</i> 677C → T risk knowledge on changes in folate intake: findings from the Food4Me study.

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