Ontology highlight
ABSTRACT:
SUBMITTER: Taylor SE
PROVIDER: S-EPMC5043584 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Open biology 20160901 9
Cellular adaptation to hypoxia occurs via a complex programme of gene expression mediated by the hypoxia-inducible factor (HIF). The oxygen labile alpha subunits, HIF-1α/-2α, form a heterodimeric transcription factor with HIF-1β and modulate gene expression. HIF-1α and HIF-2α possess similar domain structure and bind to the same consensus sequence. However, they have different oxygen-dependent stability and activate distinct genes. To better understand these differences, we used fluorescent micr ...[more]