Animal models of systemic sclerosis: their utility and limitations.
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ABSTRACT:
SUBMITTER: Artlett CM
PROVIDER: S-EPMC5045111 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Animal models of systemic sclerosis: their utility and limitations.
Open access rheumatology : research and reviews 20140701
Without doubt, animal models have provided significant insights into our understanding of the rheumatological diseases; however, no model has accurately replicated all aspects of any autoimmune disease. Recent years have seen a plethora of knockouts and transgenics that have contributed to our knowledge of the initiating events of systemic sclerosis, an autoimmune disease. In this review, the focus is on models of systemic sclerosis and how they have progressed our understanding of fibrosis and ...[more]
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