Ontology highlight
ABSTRACT:
SUBMITTER: Snyder MJ
PROVIDER: S-EPMC5045178 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Snyder Martha J MJ Lau Alyssa C AC Brouhard Elizabeth A EA Davis Michael B MB Jiang Jianhao J Sifuentes Margarita H MH Csankovszki Györgyi G
PLoS genetics 20160930 9
Higher order chromosome structure and nuclear architecture can have profound effects on gene regulation. We analyzed how compartmentalizing the genome by tethering heterochromatic regions to the nuclear lamina affects dosage compensation in the nematode C. elegans. In this organism, the dosage compensation complex (DCC) binds both X chromosomes of hermaphrodites to repress transcription two-fold, thus balancing gene expression between XX hermaphrodites and XO males. X chromosome structure is dis ...[more]