Expression profiling of constitutive mast cells reveals a unique identity within the immune system.
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ABSTRACT:
SUBMITTER: Dwyer DF
PROVIDER: S-EPMC5045264 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Expression profiling of constitutive mast cells reveals a unique identity within the immune system.
Dwyer Daniel F DF Barrett Nora A NA Austen K Frank KF
Nature immunology 20160502 7
Mast cells are evolutionarily ancient sentinel cells. Like basophils, mast cells express the high-affinity receptor for immunoglobulin E (IgE) and have been linked to host defense and diverse immune-system-mediated diseases. To better characterize the function of these cells, we assessed the transcriptional profiles of mast cells isolated from peripheral connective tissues and basophils isolated from spleen and blood. We found that mast cells were transcriptionally distinct, clustering independe ...[more]
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