Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma.
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ABSTRACT:
SUBMITTER: Cinegaglia NC
PROVIDER: S-EPMC5045367 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma.
Cinegaglia Naiara C NC Andrade Sonia Cristina S SC Tokar Tomas T Pinheiro Maísa M Severino Fábio E FE Oliveira Rogério A RA Hasimoto Erica N EN Cataneo Daniele C DC Cataneo Antônio J M AJ Defaveri Júlio J Souza Cristiano P CP Marques Márcia M C MM Carvalho Robson F RF Coutinho Luiz L LL Gross Jefferson L JL Rogatto Silvia R SR Lam Wan L WL Jurisica Igor I Reis Patricia P PP
Oncotarget 20160501 20
Herein, we aimed at identifying global transcriptome microRNA (miRNA) changes and miRNA target genes in lung adenocarcinoma. Samples were selected as training (N = 24) and independent validation (N = 34) sets. Tissues were microdissected to obtain >90% tumor or normal lung cells, subjected to miRNA transcriptome sequencing and TaqMan quantitative PCR validation. We further integrated our data with published miRNA and mRNA expression datasets across 1,491 lung adenocarcinoma and 455 normal lung s ...[more]
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