Ontology highlight
ABSTRACT:
SUBMITTER: Wang A
PROVIDER: S-EPMC5045383 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Wang Aoli A Wu Hong H Chen Cheng C Hu Chen C Qi Ziping Z Wang Wenchao W Yu Kailin K Liu Xiaochuan X Zou Fengming F Zhao Zheng Z Wu Jiaxin J Liu Juan J Liu Feiyang F Wang Li L Stone Richard M RM Galinksy Ilene A IA Griffin James D JD Zhang Shanchun S Weisberg Ellen L EL Liu Jing J Liu Qingsong Q
Oncotarget 20160501 20
The FLT3-ITD mutation is one of the most prevalent oncogenic mutations in AML. Several FLT3 kinase inhibitors have shown impressive activity in clinical evaluation, however clinical responses are usually transient and clinical effects are rapidly lost due to drug resistance. One of the resistance mechanisms in the AML refractory patients involves FLT3-ligand induced reactivation of AKT and/or ERK signaling via FLT3 wt kinase. Via a screen of numerous AKT kinase inhibitors, we identified the well ...[more]