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Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma.

ABSTRACT: Glioblastoma (GBM) is an essentially incurable and rapidly fatal cancer, with few markers predicting a favourable prognosis. Here we report that the transcription factor NFIB is associated with significantly improved survival in GBM. NFIB expression correlates inversely with astrocytoma grade and is lowest in mesenchymal GBM. Ectopic expression of NFIB in low-passage, patient-derived classical and mesenchymal subtype GBM cells inhibits tumourigenesis. Ectopic NFIB expression activated phospho-STAT3 signalling only in classical and mesenchymal GBM cells, suggesting a mechanism through which NFIB may exert its context-dependent tumour suppressor activity. Finally, NFIB expression can be induced in GBM cells by drug treatment with beneficial effects.

SUBMITTER: Stringer BW

PROVIDER: S-EPMC5045397 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma.

Stringer Brett W BW Bunt Jens J Day Bryan W BW Barry Guy G Jamieson Paul R PR Ensbey Kathleen S KS Bruce Zara C ZC Goasdoué Kate K Vidal Hélène H Charmsaz Sara S Smith Fiona M FM Cooper Leanne T LT Piper Michael M Boyd Andrew W AW Richards Linda J LJ

Oncotarget 20160501 20

Glioblastoma (GBM) is an essentially incurable and rapidly fatal cancer, with few markers predicting a favourable prognosis. Here we report that the transcription factor NFIB is associated with significantly improved survival in GBM. NFIB expression correlates inversely with astrocytoma grade and is lowest in mesenchymal GBM. Ectopic expression of NFIB in low-passage, patient-derived classical and mesenchymal subtype GBM cells inhibits tumourigenesis. Ectopic NFIB expression activated phospho-ST ...[more]

PMID: 27083054

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