Ontology highlight
ABSTRACT:
SUBMITTER: Wang YC
PROVIDER: S-EPMC5045417 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Wang Yu-Chih YC Tsai Cheng-Fang CF Chuang Hsiao-Li HL Chang Yi-Chih YC Chen Hung-Sheng HS Lee Jau-Nan JN Tsai Eing-Mei EM
Oncotarget 20160501 20
Understanding the regulatory mechanisms unique to breast cancer stem cells (BCSCs) is required to control breast cancer metastasis. We found that phthalates promote BCSCs in human breast cancer cell cultures and xenograft tumors. A toxic phthalate, benzyl butyl phthalate (BBP), activated aryl hydrocarbon receptor in breast cancer cells to stimulate sphingosine kinase 1 (SPHK1)/sphingosine 1-phosphate (S1P)/sphingosine-1-phosphate receptor 3 (S1PR3) signaling and enhance formation of metastasis-i ...[more]