Dataset Information

MR fingerprinting for rapid quantification of myocardial T1 , T2 , and proton spin density.

ABSTRACT: To introduce a two-dimensional MR fingerprinting (MRF) technique for quantification of T1 , T2 , and M0 in myocardium.An electrocardiograph-triggered MRF method is introduced for mapping myocardial T1 , T2 , and M0 during a single breath-hold in as short as four heartbeats. The pulse sequence uses variable flip angles, repetition times, inversion recovery times, and T2 preparation dephasing times. A dictionary of possible signal evolutions is simulated for each scan that incorporates the subject's unique variations in heart rate. Aspects of the sequence design were explored in simulations, and the accuracy and precision of cardiac MRF were assessed in a phantom study. In vivo imaging was performed at 3 Tesla in 11 volunteers to generate native parametric maps.T1 and T2 measurements from the proposed cardiac MRF sequence correlated well with standard spin echo measurements in the phantom study (R2 ?>?0.99). A Bland-Altman analysis revealed good agreement for myocardial T1 measurements between MRF and MOLLI (bias 1 ms, 95% limits of agreement -72 to 72 ms) and T2 measurements between MRF and T2 -prepared balanced steady-state free precession (bias, -2.6 ms; 95% limits of agreement, -8.5 to 3.3 ms).MRF can provide quantitative single slice T1 , T2 , and M0 maps in the heart within a single breath-hold. Magn Reson Med 77:1446-1458, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

SUBMITTER: Hamilton JI

PROVIDER: S-EPMC5045735 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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MR fingerprinting for rapid quantification of myocardial T<sub>1</sub> , T<sub>2</sub> , and proton spin density.

Hamilton Jesse I JI Jiang Yun Y Chen Yong Y Ma Dan D Lo Wei-Ching WC Griswold Mark M Seiberlich Nicole N

Magnetic resonance in medicine 20160401 4

<h4>Purpose</h4>To introduce a two-dimensional MR fingerprinting (MRF) technique for quantification of T<sub>1</sub> , T<sub>2</sub> , and M<sub>0</sub> in myocardium.<h4>Methods</h4>An electrocardiograph-triggered MRF method is introduced for mapping myocardial T<sub>1</sub> , T<sub>2</sub> , and M<sub>0</sub> during a single breath-hold in as short as four heartbeats. The pulse sequence uses variable flip angles, repetition times, inversion recovery times, and T<sub>2</sub> preparation dephasi ...[more]

PMID: 27038043

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Project description:To prospectively compare an investigational version of a complex-based chemical shift-based fat fraction magnetic resonance (MR) imaging method with MR spectroscopy for the quantification of hepatic steatosis.This study was approved by the institutional review board and was HIPAA compliant. Written informed consent was obtained before all studies. Fifty-five patients (31 women, 24 men; age range, 24-71 years) were prospectively imaged at 1.5 T with quantitative MR imaging and single-voxel MR spectroscopy, each within a single breath hold. The effects of T2 correction, spectral modeling of fat, and magnitude fitting for eddy current correction on fat quantification with MR imaging were investigated by reconstructing fat fraction images from the same source data with different combinations of error correction. Single-voxel T2-corrected MR spectroscopy was used to measure fat fraction and served as the reference standard. All MR spectroscopy data were postprocessed at a separate institution by an MR physicist who was blinded to MR imaging results. Fat fractions measured with MR imaging and MR spectroscopy were compared statistically to determine the correlation (r(2)), and the slope and intercept as measures of agreement between MR imaging and MR spectroscopy fat fraction measurements, to determine whether MR imaging can help quantify fat, and examine the importance of T2 correction, spectral modeling of fat, and eddy current correction. Two-sided t tests (significance level, P = .05) were used to determine whether estimated slopes and intercepts were significantly different from 1.0 and 0.0, respectively. Sensitivity and specificity for the classification of clinically significant steatosis were evaluated.Overall, there was excellent correlation between MR imaging and MR spectroscopy for all reconstruction combinations. However, agreement was only achieved when T2 correction, spectral modeling of fat, and magnitude fitting for eddy current correction were used (r(2) = 0.99; slope ± standard deviation = 1.00 ± 0.01, P = .77; intercept ± standard deviation = 0.2% ± 0.1, P = .19).T1-independent chemical shift-based water-fat separation MR imaging methods can accurately quantify fat over the entire liver, by using MR spectroscopy as the reference standard, when T2 correction, spectral modeling of fat, and eddy current correction methods are used.

Dataset Information

MR fingerprinting for rapid quantification of myocardial T1 , T2 , and proton spin density.

Publications

MR fingerprinting for rapid quantification of myocardial T<sub>1</sub> , T<sub>2</sub> , and proton spin density.

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