Longitudinal Perspective on Managing Refractory Eosinophilic Esophagitis.

ABSTRACT:

Background

One half to one third of the patients with eosinophilic esophagitis (EoE) do not achieve histological remission on initial treatment. We wondered whether these treatment failure patients are a distinct clinical subset.

Objective

To analyze EoE treatment outcomes in a predominantly pediatric population.

Methods

We reviewed 100 serial EoE cases at Massachusetts General Hospital starting from 2007. We defined histological remission as peak esophageal eosinophil count of less than 10/hpf.

Results

Ninety-seven patients with EoE underwent initial treatments: 54 of 81 (67%) responded to dietary therapy, and 9 of 16 (56%) responded to topical glucocorticoids. Of the 34 who failed initial treatment, 24 underwent various second treatment regimens and 54% (13 o

SUBMITTER: Leung J 

PROVIDER: S-EPMC5045894 | biostudies-literature | 2015 Nov-Dec

REPOSITORIES: biostudies-literature