Ontology highlight
ABSTRACT:
SUBMITTER: Doerflinger M
PROVIDER: S-EPMC5046154 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Doerflinger Marcel M Glab Jason J Nedeva Christina C Jose Irvin I Lin Ann A O'Reilly Lorraine L Allison Cody C Pellegrini Marc M Hotchkiss Richard S RS Puthalakath Hamsa H
Scientific reports 20161003
Sepsis-induced lymphopenia is a major cause of morbidities in intensive care units and in populations with chronic conditions such as renal failure, diabetes, HIV and alcohol abuse. Currently, other than supportive care and antibiotics, there are no treatments for this condition. We developed an in vitro assay to understand the role of the ER-stress-mediated apoptosis process in lymphocyte death during polymicrobial sepsis, which was reproducible in in vivo mouse models. Modulating ER stress usi ...[more]