Dataset Information

Increased pancreatic cancer risk following radiotherapy for testicular cancer.

ABSTRACT:

Background

Pancreatic cancer risk is elevated among testicular cancer (TC) survivors. However, the roles of specific treatments are unclear.

Methods

Among 23?982 5-year TC survivors diagnosed during 1947-1991, doses from radiotherapy to the pancreas were estimated for 80 pancreatic cancer patients and 145 matched controls. Chemotherapy details were recorded. Logistic regression was used to estimate odds ratios (ORs).

Results

Cumulative incidence of second primary pancreatic cancer was 1.1% at 30 years after TC diagnosis. Radiotherapy (72 (90%) cases and 115 (80%) controls) was associated with a 2.9-fold (95% confidence interval (CI) 1.0-7.8) increased risk. The OR increased linearly by 0.12 per Gy to the pancreas (P-trend<0.001), with an OR of 4.6 (95% CI 1.9-11.0) for ?25?Gy vs <25?Gy. Radiation-related risks remained elevated ?20 years after TC diagnosis (P=0.020). The risk increased with the number of cycles of chemotherapy with alkylating or platinum agents (P=0.057), although only one case was exposed to platinum.

Conclusions

A dose-response relationship exists between radiation to the pancreas and subsequent cancer risk, and persists for over 20 years. These excesses, although small, should be considered when radiotherapy with exposure to the pancreas is considered for newly diagnosed patients. Additional data are needed on the role of chemotherapy.

SUBMITTER: Hauptmann M

PROVIDER: S-EPMC5046216 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Publications

Increased pancreatic cancer risk following radiotherapy for testicular cancer.

Hauptmann Michael M Børge Johannesen Tom T Gilbert Ethel S ES Stovall Marilyn M van Leeuwen Flora E FE Rajaraman Preetha P Smith Susan A SA Weathers Rita E RE Aleman Berthe M P BM Andersson Michael M Curtis Rochelle E RE Dores Graça M GM Fraumeni Joseph F JF Hall Per P Holowaty Eric J EJ Joensuu Heikki H Kaijser Magnus M Kleinerman Ruth A RA Langmark Frøydis F Lynch Charles F CF Pukkala Eero E Storm Hans H HH Vaalavirta Leila L van den Belt-Dusebout Alexandra W AW Morton Lindsay M LM Fossa Sophie D SD Travis Lois B LB

British journal of cancer 20160906 7

<h4>Background</h4>Pancreatic cancer risk is elevated among testicular cancer (TC) survivors. However, the roles of specific treatments are unclear.<h4>Methods</h4>Among 23 982 5-year TC survivors diagnosed during 1947-1991, doses from radiotherapy to the pancreas were estimated for 80 pancreatic cancer patients and 145 matched controls. Chemotherapy details were recorded. Logistic regression was used to estimate odds ratios (ORs).<h4>Results</h4>Cumulative incidence of second primary pancreatic ...[more]

PMID: 27599043

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Dataset Information

Increased pancreatic cancer risk following radiotherapy for testicular cancer.

Background

Methods

Results

Conclusions

Publications

Increased pancreatic cancer risk following radiotherapy for testicular cancer.

Similar Datasets

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