Ontology highlight
ABSTRACT:
SUBMITTER: Chen T
PROVIDER: S-EPMC5046712 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Chen Tianda T Wu Qinwei Q Zhang Yang Y Lu Tianlan T Yue Weihua W Zhang Dai D
Frontiers in molecular neuroscience 20161003
<b>Background:</b> Transcription factor 4 (TCF4) is found to be associated with schizophrenia. TCF4 mutations also cause Pitt-Hopkins Syndrome, a neurodevelopmental disorder associated with severe mental retardation. However, the function of TCF4 during brain development remains unclear. <b>Results:</b> Here, we report that <i>Tcf4</i> is expressed in the developing cerebral cortex. <i>In utero</i> suppression of <i>Tcf4</i> arrested neuronal migration, leading to accumulation of ectopic neurons ...[more]