Ontology highlight
ABSTRACT:
SUBMITTER: Koledova Z
PROVIDER: S-EPMC5047180 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Koledova Zuzana Z Zhang Xiaohong X Streuli Charles C Clarke Robert B RB Klein Ophir D OD Werb Zena Z Lu Pengfei P
Proceedings of the National Academy of Sciences of the United States of America 20160912 39
The role of the local microenvironment in influencing cell behavior is central to both normal development and cancer formation. Here, we show that sprouty 1 (SPRY1) modulates the microenvironment to enable proper mammary branching morphogenesis. This process occurs through negative regulation of epidermal growth factor receptor (EGFR) signaling in mammary stroma. Loss of SPRY1 resulted in up-regulation of EGFR-extracellular signal-regulated kinase (ERK) signaling in response to amphiregulin and ...[more]