Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational study.

ABSTRACT:

Background

We characterized cardiac surgery-induced dynamic changes of the corrected QT (QTc) interval and tested the hypothesis that genetic factors are associated with perioperative QTc prolongation independent of clinical and procedural factors.

Methods

All study subjects were ascertained from a prospective study of patients who underwent elective cardiac surgery during August 1999 to April 2002. We defined a prolonged QTc interval as > 440 msec, measured from 24-hr pre- and postoperative 12-lead electrocardiograms. The association of 37 single nucleotide polymorphisms (SNPs) in 21 candidate genes -involved in modulating arrhythmia susceptibility pathways with postoperative QTc changes- was investigated in a two-stage design with a stage I cohort (n = 497) nested within a

SUBMITTER: Kertai MD 

PROVIDER: S-EPMC5048102 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature