Ontology highlight
ABSTRACT:
SUBMITTER: Tanigawa H
PROVIDER: S-EPMC5048131 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Tanigawa Hiroki H Miyata Keishi K Tian Zhe Z Aoi Jun J Kadomatsu Tsuyoshi T Fukushima Satoshi S Ogata Aki A Takeda Naoki N Zhao Jiabin J Zhu Shunshun S Terada Kazutoyo K Endo Motoyoshi M Morinaga Jun J Sugizaki Taichi T Sato Michio M Morioka Masaki Suimye MS Manabe Ichiro I Mashimo Youichi Y Hata Akira A Taketomi Yoshitaka Y Yamamoto Kei K Murakami Makoto M Araki Kimi K Jinnin Masatoshi M Ihn Hironobu H Oike Yuichi Y
Scientific reports 20161004
Psoriasis is a chronic inflammatory skin disease marked by aberrant tissue repair. Mutant mice modeling psoriasis skin characteristics have provided useful information relevant to molecular mechanisms and could serve to evaluate therapeutic strategies. Here, we found that epidermal ANGPTL6 expression was markedly induced during tissue repair in mice. Analysis of mice overexpressing ANGPTL6 in keratinocytes (K14-Angptl6 Tg mice) revealed that epidermal ANGPTL6 activity promotes aberrant epidermal ...[more]