Ontology highlight
ABSTRACT:
SUBMITTER: Raimondi F
PROVIDER: S-EPMC5048291 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Raimondi Francesco F Singh Gurdeep G Betts Matthew J MJ Apic Gordana G Vukotic Ranka R Andreone Pietro P Stein Lincoln L Russell Robert B RB Russell Robert B RB
Scientific reports 20161004
To attain a deeper understanding of diseases like cancer, it is critical to couple genetics with biomolecular mechanisms. High-throughput sequencing has identified thousands of somatic mutations across dozens of cancers, and there is a pressing need to identify the few that are pathologically relevant. Here we use protein structure and interaction data to interrogate nonsynonymous somatic cancer mutations, identifying a set of 213 molecular interfaces (protein-protein, -small molecule or -nuclei ...[more]