Ontology highlight
ABSTRACT:
SUBMITTER: Ye Q
PROVIDER: S-EPMC5048352 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Ye Qiaozhen Q Ur Sarah N SN Su Tiffany Y TY Corbett Kevin D KD
The EMBO journal 20160804 19
In budding yeast, the monopolin complex mediates sister kinetochore cross-linking and co-orientation in meiosis I. The CK1δ kinase Hrr25 is critical for sister kinetochore co-orientation, but its roles are not well understood. Here, we present the structures of Hrr25 and its complex with the monopolin subunit Mam1. Hrr25 possesses a "central domain" that packs tightly against the kinase C-lobe, adjacent to the binding site for Mam1. Together, the Hrr25 central domain and Mam1 form a novel, conti ...[more]