COMT and ANKK1 Genetics Interact With Depression to Influence Behavior Following Severe TBI: An Initial Assessment.

ABSTRACT:

Objective

Genetic variations in the dopamine (DA) system are associated with cortical-striatal behavior in multiple populations. This study assessed associations of functional polymorphisms in the ankyrin repeat and kinase domain (ANKK1; Taq1a) and catechol-O-methyltransferase (COMT; Val158Met) genes with behavioral dysfunction following traumatic brain injury (TBI).

Participants

This was a prospective study of 90 survivors of severe TBI recruited from a level 1 trauma center.

Main measures

The Frontal Systems Behavior Scale, a self- or family report questionnaire evaluating behavior associated with frontal lobe dysfunction, was completed 6 and 12 months postinjury. Depression was measured concurrently with the Patient Health Questionnaire-9. Study participants were g

SUBMITTER: Myrga JM 

PROVIDER: S-EPMC5048493 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature