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A Mutasynthetic Library of Platensimycin and Platencin Analogues.

ABSTRACT: Inactivation of ptmB1, ptmB2, ptmT2, or ptmC in Streptomyces platensis SB12029, a platensimycin (PTM) and platencin (PTN) overproducer, revealed that PTM and PTN biosynthesis features two distinct moieties that are individually constructed and convergently coupled to afford PTM and PTN. A focused library of PTM and PTN analogues was generated by mutasynthesis in the ?ptmB1 mutant S. platensis SB12032. Of the 34 aryl variants tested, 18 were incorporated with high titers.

SUBMITTER: Dong LB 

PROVIDER: S-EPMC5048679 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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A Mutasynthetic Library of Platensimycin and Platencin Analogues.

Dong Liao-Bin LB   Rudolf Jeffrey D JD   Shen Ben B  

Organic letters 20160906 18

Inactivation of ptmB1, ptmB2, ptmT2, or ptmC in Streptomyces platensis SB12029, a platensimycin (PTM) and platencin (PTN) overproducer, revealed that PTM and PTN biosynthesis features two distinct moieties that are individually constructed and convergently coupled to afford PTM and PTN. A focused library of PTM and PTN analogues was generated by mutasynthesis in the ΔptmB1 mutant S. platensis SB12032. Of the 34 aryl variants tested, 18 were incorporated with high titers. ...[more]

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