Ontology highlight
ABSTRACT:
SUBMITTER: Respuela P
PROVIDER: S-EPMC5048917 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Cell stem cell 20160101 1
Following implantation, mouse epiblast cells transit from a naive to a primed state in which they are competent for both somatic and primordial germ cell (PGC) specification. Using mouse embryonic stem cells as an in vitro model to study the transcriptional regulatory principles orchestrating peri-implantation development, here we show that the transcription factor Foxd3 is necessary for exit from naive pluripotency and progression to a primed pluripotent state. During this transition, Foxd3 act ...[more]