Ontology highlight
ABSTRACT:
SUBMITTER: Baccile JA
PROVIDER: S-EPMC5049701 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Baccile Joshua A JA Spraker Joseph E JE Le Henry H HH Brandenburger Eileen E Gomez Christian C Bok Jin Woo JW Macheleidt Juliane J Brakhage Axel A AA Hoffmeister Dirk D Keller Nancy P NP Schroeder Frank C FC
Nature chemical biology 20160411 6
Natural product discovery efforts have focused primarily on microbial biosynthetic gene clusters (BGCs) containing large multimodular polyketide synthases and nonribosomal peptide synthetases; however, sequencing of fungal genomes has revealed a vast number of BGCs containing smaller NRPS-like genes of unknown biosynthetic function. Using comparative metabolomics, we show that a BGC in the human pathogen Aspergillus fumigatus named fsq, which contains an NRPS-like gene lacking a condensation dom ...[more]