Ontology highlight
ABSTRACT:
SUBMITTER: Lyu J
PROVIDER: S-EPMC5049767 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Lyu Jie J Cao Jinfeng J Zhang Peiming P Liu Yang Y Cheng Hongtao H
PloS one 20161004 10
The processes governing tumor growth and angiogenesis are codependent. To study the relationship between them, we proposed a coupled hybrid continuum-discrete model. In this model, tumor cells, their microenvironment (extracellular matrixes, matrix-degrading enzymes, and tumor angiogenic factors), and their network of blood vessels, described by a series of discrete points, were considered. The results of numerical simulation reveal the process of tumor growth and the change in microenvironment ...[more]