Ontology highlight
ABSTRACT:
SUBMITTER: Hayano T
PROVIDER: S-EPMC5049788 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Hayano Takahide T Matsui Hiroshi H Nakaoka Hirofumi H Ohtake Nobuaki N Hosomichi Kazuyoshi K Suzuki Kazuhiro K Inoue Ituro I
PloS one 20161004 10
Prostate cancer (PC) is the second most common cancer in men. Family history is the major risk factor for PC. Only two susceptibility genes were identified in PC, BRCA2 and HOXB13. A comprehensive search of germline variants for patients with PC has not been reported in Japanese families. In this study, we conducted exome sequencing followed by Sanger sequencing to explore responsible germline variants in 140 Japanese patients with PC from 66 families. In addition to known susceptibility genes, ...[more]