Synthesis and preclinical evaluation of an Al18F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand.
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ABSTRACT:
SUBMITTER: Boschi S
PROVIDER: S-EPMC5050145 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
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Synthesis and preclinical evaluation of an Al<sup>18</sup>F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand.
Boschi Stefano S Lee Jason T JT Beykan Seval S Slavik Roger R Wei Liu L Spick Claudio C Eberlein Uta U Buck Andreas K AK Lodi Filippo F Cicoria Gianfranco G Czernin Johannes J Lassmann Michael M Fanti Stefano S Herrmann Ken K
European journal of nuclear medicine and molecular imaging 20160622 12
<h4>Purpose</h4>The aim of this study was to synthesize and preclinically evaluate an <sup>18</sup>F-PSMA positron emission tomography (PET) tracer. Prostate-specific membrane antigen (PSMA) specificity, biodistribution, and dosimetry in healthy and tumor-bearing mice were determined.<h4>Methods</h4>Several conditions for the labeling of <sup>18</sup>F-PSMA-11 via <sup>18</sup>F-AlF-complexation were screened to study the influence of reaction temperature, peptide amount, ethanol volume, and rea ...[more]
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