Ontology highlight
ABSTRACT:
SUBMITTER: Homet Moreno B
PROVIDER: S-EPMC5050168 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Homet Moreno Blanca B Zaretsky Jesse M JM Garcia-Diaz Angel A Tsoi Jennifer J Parisi Giulia G Robert Lidia L Meeth Katrina K Ndoye Abibatou A Bosenberg Marcus M Weeraratna Ashani T AT Graeber Thomas G TG Comin-Anduix Begoña B Hu-Lieskovan Siwen S Ribas Antoni A
Cancer immunology research 20160902 10
The programmed cell death protein 1 (PD-1) limits effector T-cell functions in peripheral tissues, and its inhibition leads to clinical benefit in different cancers. To better understand how PD-1 blockade therapy modulates the tumor-host interactions, we evaluated three syngeneic murine tumor models, the BRAF<sup>V600E</sup>-driven YUMM1.1 and YUMM2.1 melanomas, and the carcinogen-induced murine colon adenocarcinoma MC38. The YUMM cell lines were established from mice with melanocyte-specific BR ...[more]