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Crystal structure of a mixed-ligand silver(I) complex of the non-steroidal anti-inflammatory drug diclofenac and pyrimidine.

ABSTRACT: In the title mixed-ligand silver(I) coordination polymeric complex with the non-steroidal anti-inflammatory drug diclofenac (C₁₄H₁₁Cl₂NO₂) (diclH) and pyrimidine (pym), namely poly[{?₂-2-[2-(2,6-di-chloro-anilino)phen-yl]acetato-?²O:O'}(?₂-pyrimidine-?²N¹:N³)silver(I)], [Ag(C₁₄H₁₀Cl₂NO₂)(C₄H₄N₂)] _n or [Ag(?-dicl)(?-pym)] _n , the very distorted tetra-hedral AgN₂O₂ coordination centres comprise two N-atom donors from bridging pym ligands [Ag-N = 2.381?(3) and 2.412?(3)?Å] and two carboxyl-ate O-atom donors from dicl ligands [Ag-O = 2.279?(2) and 2.280?(2)?Å], which bridge Ag atoms, giving a centrosymmetric dinuclear units with a short Ag?Ag separation [2.8931?(5)?Å]. Within the units are short intra-ligand C-Cl??(pym) inter-actions [3.6409?(15)?Å]. The units are linked through the bridging N atoms of the pym ligand into a two-dimensional sheet-polymer structure lying parallel to (100) and stabilized by inter-ring ?-? inter-actions between the pym ligands [Cg?Cg = 3.4199?(17)?Å]. Additional inter-unit C-H?O and C-H?Cg hydrogen-bonding inter-actions between the sheets give an overall three-dimensional structure.

SUBMITTER: Hamamci Alisir S

PROVIDER: S-EPMC5050780 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Crystal structure of a mixed-ligand silver(I) complex of the non-steroidal anti-inflammatory drug diclofenac and pyrimidine.

Hamamci Alisir Sevim S Dege Necmi N

Acta crystallographica. Section E, Crystallographic communications 20160927 Pt 10

In the title mixed-ligand silver(I) coordination polymeric complex with the non-steroidal anti-inflammatory drug diclofenac (C14H11Cl2NO2) (diclH) and pyrimidine (pym), namely poly[{μ2-2-[2-(2,6-di-chloro-anilino)phen-yl]acetato-κ2O:O'}(μ2-pyrimidine-κ2N1:N3)silver(I)], [Ag(C14H10Cl2NO2)(C4H4N<s ...[more]

PMID: 27746945

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Project description:BACKGROUND AND OBJECTIVES:Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with AKI. Their association with nephrotic syndrome has not been systematically studied. This study aimed to assess the risk of nephrotic syndrome associated with NSAID use. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:A matched case-control study was performed in the UK primary care database. Cases were patients with a first diagnosis of nephrotic syndrome and controls were those without nephrotic syndrome. NSAID exposure (grouped either based on cyclooxygenase enzyme selectivity and chemical groups) was classified as either current (use at the nephrotic syndrome diagnosis date and corresponding date in the control group), recent, or past use. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analysis. RESULTS:We included 2620 cases and 10,454 controls. Compared with non-use, current use of 15-28 days and >28 days of conventional NSAIDs was associated with a higher relative risk of nephrotic syndrome: adjusted OR, 1.34; 95% CI, 1.06 to 1.70, and OR, 1.42; 95% CI, 0.79 to 2.55, respectively. Also, recent use (discontinuation 1-2 months before nephrotic syndrome diagnosis date; OR, 1.55; 95% CI, 1.11 to 2.15) and past use (discontinuation 2 months-2 years; OR, 1.24; 95% CI, 1.07 to 1.43), but not current use of <15 days (OR, 0.78; 95% CI, 0.46 to 1.31) nor past use (discontinuation >2 years; OR, 0.96; 95% CI, 0.85 to 1.09) were associated with a higher relative risk of nephrotic syndrome as well as past use of selective COX-2 inhibitors (discontinuation 2-24 months; OR, 1.24; 95% CI, 0.98 to 1.58). Categorization based on chemical groups showed that acetic acid and propionic acid derivatives were associated with a higher risk of nephrotic syndrome. CONCLUSIONS:The use of conventional NSAIDs was associated with a higher risk of nephrotic syndrome starting from at least 2 weeks of exposure, as well as for recent and past exposure up to 2 years before the diagnosis of nephrotic syndrome. This higher risk appeared mainly attributable to acetic acid and propionic acid derivatives.

Dataset Information

Crystal structure of a mixed-ligand silver(I) complex of the non-steroidal anti-inflammatory drug diclofenac and pyrimidine.

Publications

Crystal structure of a mixed-ligand silver(I) complex of the non-steroidal anti-inflammatory drug diclofenac and pyrimidine.

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