DNA Walker-Regulated Cancer Cell Growth Inhibition.
Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC5051347 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
DNA Walker-Regulated Cancer Cell Growth Inhibition.
Li Feiran F Cha Tae-Gon TG Pan Jing J Ozcelikkale Altug A Han Bumsoo B Choi Jong Hyun JH
Chembiochem : a European journal of chemical biology 20160428 12
We demonstrate a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. In this system, AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anticancer oligonucleotides are controlled by the walker operation. With a walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in situ cancer cell growth ...[more]
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